Polyprenols extract supplementation modulates scopolamine-induced non-spatial and spatial memory impairments in rats
Julia Fedotova1,2, Olga Volkova2
1- Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology of the
Russian Academy of Sciences, 6 Emb. Makarova, St. Petersburg 199034, Russia;
firstname.lastname@example.org, Tel: +7 911 287 92 73, Fax: +7 812 328 05 01
2 — Faculty of Food Biotechnologies and Engineering, ITMO University, 49
Kronverksky pr., St. Petersburg 197101, Russia.
The present study was created to assess the effects of chronic polyprenols extract administration (1.0, 5 and 10 mg/kg, orally, once daily, 14 days) in a scopolamine-induced amnesia. The experimental model of amnesia was created by scopolamine (1.0 mg/kg, s.c.) injection once daily, 14 days. Memory performance was evaluated using the passive avoidance and the Morris water maze tests and the spontaneous locomotor activity was assessed using the open field test. Moreover, we tested acetylcholinesterase (AChE) activity in the brain of the rats with scopolamine-induced amnesia. The polyprenols extract treatment at dose of 1 mg/kg significantly ameliorated the impaired cognitive performance induced by scopolamine injection in the rats. The polyprenols extract treatment at dose of 1 mg/kg significantly increased locomotor activity, rearing and grooming events and so significantly reversed the behavioral impairments in the rats with scopolamine-induced amnesia in the open field test.
Biochemical data showed that polyprenols extract treatment at dose of 1 mg/kg significantly decreased and completely restored AChE activity in the brain of the rats with scopolamine-induced amnesia. The results of the present study suggest that chronic polyprenols extract treatment results in memory-enhancing effects of the rats in the passive avoidance test and Morris water maze in an animal model of scopolamine-induced amnesia.
Keywords: Acetylcholinesterase; Polyprenols extract; Learning; Memory; Scopolamine.